EFFECT OF THE ZINC PHTHALOCYANINE MEDIATED PHOTODYNAMIC THERAPY ON CYTOSKELETAL APPARATUS OF HELA CELLS

Authors

  • Barbora Hošíková Department of Medical Biophysics, Faculty of medicine and Dentistry, Palacky University, Olomouc
  • Svatopluk Binder
  • René Lenobel
  • Jakub Malohlava
  • Jakub Hošík
  • Jana Jiravová
  • Lukáš Malina
  • Jana Zapletalová
  • Hana Kolářová

DOI:

https://doi.org/10.14311/CTJ.2019.2.01

Keywords:

Photodynamic therapy, ROS, phthalocyanines, cytoskeletal apparatus

Abstract

This study deals with the utilization of photosensitizer (λmax ~ 660 nm) from the group of the phthalocyanines, in photodynamic therapy. Effect of the zinc phthalocyanine photosensitizer mediated photodynamic therapy was evaluated in vitro on the tumor cell line – HeLa (cervical cancer cells) using mass spectrometry and atomic force and fluorescent microscopy techniques.

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Published

2019-07-01

Issue

Vol. 49 No. 2 (2019)

Section

Original Research

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