FEASIBILITY OF RADIOIODINE DOSIMETRY USING A SMALL FIELD OF VIEW GAMMACAMERA; PILOT STUDY
Keywords:
radioiodine, therapy, dosimetry, quantitative imagingAbstract
Nowadays, it is crucial to deal with the dosimetry issues in the light of 2013/59 EURATOM recommendation, where it is clearly defined that dosimetry will be required even for the targeted radionuclide therapy (TRT). The aim of this pilot study was to investigate and to verify the possibilities of dosimetry for patients undergoing first Radioiodine therapy (RAIT) using a small single head mobile gamma camera. Camera Solo mobile was used for quantitative imaging of 131I accumulation in remnants of patients' thyroids and 131I accumulating nodes (neck region). Vials with a known activity of 131I were used to calibrate the system. The patient-volunteers were around 3 months after thyreoablation due to thyroid carcinoma. The weight of the accumulating remnants or nodes was established using ultrasound or roughly estimated using phantom measurements. The absorbed doses within remnants or nodes vary from 40 Gy up to 780 Gy with an uncertainty from 25% up to 100% depending mainly on the mass of the remnants estimation. A consequent follow-up is being done. The dose assessment could be done using cheaper small single-head gammacamera what would safe time of the standard ones. Uncertainty is supposed to be significantly reduced by further processes optimization.
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Copyright (c) 2017 Pavel Solný, Petr Vlček, Lenka Jonášová, Jaroslav Zimák
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