Evaluation of Bioelectrical Impedance Spectroscopy for the Assessment of Extracellular Body Water

Sören Weyer, Lisa Röthlingshöfer, Marian Walter, Steffen Leonhardt


This study evaluates bioelectrical impedance spectroscopy (BIS) measurements to detect body fluid status. The multifrequency impedance measurements were performed in five female pigs. Animals were connected to an extracorporeal membrane oxygenation device during a lung disease experiment and fluid balance was recorded. Every 15 min the amount of fluid infusion and the weight of the urine drainage bag was recorded. From the fluid intake and output, the fluid balance was calculated. These data were compared with values calculated from a mathematical model, based on the extracellular tissue resistance and the Hanai Mixture theory. The extracellular tissue resistance was also measured with BIS. These experimental results strongly support the feasibility and clinical value of BIS for in vivo assessment of the hydration status.


Bioelectrical impedance spectroscopy; fluid status; body composition; Hanai Mixture theory

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ISSN 1210-2709 (Print)
ISSN 1805-2363 (Online)
Published by the Czech Technical University in Prague