VLIV ULTRAZVUKU NA ÚČINNOST FOTODYNAMICKÉ TERAPIE – IN VITRO STUDIE

Klára Pížová, Kateřina Tománková, Kateřina Langová, Adéla Hanáková, Hana Lenobelová, Hana Zapletalová, Jakub Malohlava, Svatopluk Binder, Robert Bajgar, Jaromír Vachutka, Ladislav Doležal, Hana Kolářová

Abstract


Photodynamic therapy (PDT) belongs in perspective modalities of cancer treatment. It is based on the tumour-selective accumulation of a photosensitizer followed by irradiation with light of a specific wavelength. PDT is widely developed nowadays due to its high specificity and selectivity along with absence of the unadvisable side-effects. Sonodynamic therapy (SDT) exploits ultrasound to induce cytotoxic effect of sensitizer. In our study we tested the possibility of combination of this therapies and icrease of efficiency. Our results suggest that irradiation in combination with application of therapeutic ultrasound increases production of reactive oxygen species and reduces viability of tumour MCF7 cells, compared to irradiation of ZnTPPS4 only, especially in the case of higher therapeutic doses. In the future, the combination of PDT and SDT can bring a new treatment modality for malignant and also nonmalignant diseases.

Keywords


photosensitizer; photodynamic therapy; sonodynamic therapy; porphyrine derivative

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ISSN 0301-5491 (Print)
ISSN 2336-5552 (Online)
Published by the Czech Society for Biomedical Engineering and Medical Informatics and the Faculty of Biomedical Engineering, Czech Technical University in Prague.