13C-METHACETINOVÝ DECHOVÝ TEST U PACIENTŮ S JATERNÍ CIRHÓZOU A DEKOMPENZOVANÝM SRDEČNÍM SELHÁNÍM

Jana Vránová, Jozef Rosina, Miluše Hendrichová, Antonín Vrána, Karolína Krátká, Jiří Horák

Abstract


An overview of new diagnostic device (Wagner Analysen Technik, Germany) is provided. This device uses the 13C stable isotope together with non-dispersive infrared selective spectroscopy for non – invasive quantification of hepatic function parameters, including kinetics (type of liver damage) and capacity (percentage of recovery yield of the liver). The short physical principle of infrared spectroscopy and acousto-optical detector of IRIS was presented. In the final section we verified the diagnostic quality of this new diagnostic device (using ANOVA and ROC analysis) on cohort of 103 patients divided into 3 groups according to diagnosis and the various level of liver damage.

Keywords


13C-methacetin; dose; cumulative dose; infrared spectroscopy; transmitance; absorbance; cirrhosis

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ISSN 0301-5491 (Print)
ISSN 2336-5552 (Online)
Published by the Czech Society for Biomedical Engineering and Medical Informatics and the Faculty of Biomedical Engineering, Czech Technical University in Prague.