GENE EXPRESSION PROFILING AFTER ANGIOGENESIS INHIBITOR TREATMENT
Keywords:
angiogenesis, photodynamic therapy, acetyl salicylic acidAbstract
The angiogenic process can be summarized as cell activation by a lack of oxygen releases angiogenic molecules that attract inflammatory and endothelial cells and promote their proliferation. Several protein fragments produced by the digestion of the blood-vessel walls intensify the proliferative activity of endothelial cells. Acetyl salicylic acid is often used as an analgesic drug to relieve minor aches and pains, a drug with antitumour activity and an anti-inflammatory medication. In our experiments we propose using the angiogenesis model and photodynamic therapy (PDT) for observing changes in angiogenesis after treatment, and also for increasing the effect of PDT by addition of angiogenesis inhibitors.
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Copyright (c) 2017 Adela Hanakova, Klara Pizova, Outti Huttala, Jertta-Riina Sarkanen, Tuula Heinonen, Dagmar Jirova, Kristyna Kejlova, Hana Kolarova
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